AHR aryl hydrocarbon receptor
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
Gene Information
Gene Symbol
AHR 196 [PubMed] [JSNP] [dbSNP]
Gene Name aryl hydrocarbon receptor
Synonyms AhR,  AHR, 
EC Number
Species Human
Chromosome Location 7p15
Orthologs Mouse  32976   Rat  82233
Unigene Cluster Hs.171189
Express placenta; uncharacterized tissue; uterus; muscle; blood; mammary gland; brain; mixed; colon; lung; eye; stomach; liver; adipose tissue; embryonic tissue; prostate; esophagus; vascular; small intestine; bone marrow; testis; lymph node; skin; kidney; connective tissue; mouth; thymus; trachea; bladder; parathyroid; cochlea; ascites; heart; whole brain; nerve; pancreas; thyroid; dorsal root ganglion; umbilical cord; tonsil; cranial nerve; bone; whole body
Restr Expr
Sequence Count 252
Subcellular Location
SwissProt Cytoplasm. Nucleus. First cytoplasmic, upon binding with ligand and interaction with a HSP90, it translocates to the nucleus
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KEGG Pathways
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Your Hyperlinks
URL Comment
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Reference Sequence
Full Length
NCBI NM_001621     NP_001612 
SwissProt AHR_HUMAN 
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GO
Classification GO Term
biological process apoptosis
cell cycle
regulation of transcription, DNA-dependent
response to stress
response to xenobiotic stimulus
signal transduction
transcription from RNA polymerase II promoter
molecular function ligand-dependent nuclear receptor activity 
protein binding 
transcription factor activity 
cellular component nucleus 
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Probe
A_23_P215566  (G4110B)
A_23_P215566  (G4112A)
TC THC2235461
TGI Annotation Aryl hydrocarbon receptor [Homo sapiens]
Phy Map chr7 (17,111,488-17,158,758)
Genetic Marker RH17631; AHR
239775_at (HG-U133_Plus_2)
202820_at (HG-U133_Plus_2)
1559035_a_at (HG-U133_Plus_2)
Hs2.290878.1.A1_3p_s_at (U133_X3P)
Hs.214174.0.A1_3p_x_at (U133_X3P)
Hs.214174.0.A1_3p_at (U133_X3P)
g5016091_3p_at (U133_X3P)
40516_at (HG_U95Av2)
87175_r_at (HG_U95E)
202820_at (HG-Focus)
239775_at (HG-U133B)
202820_at (HG-U133A_2)
202820_at (HG-U133A)
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OMIM
MIMID Type Title
600253 gene ARYL HYDROCARBON RECEPTOR; AHR
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Related Gene
19/19 shown
Gene Symbol Gene Name Score  
HTL2 hypotrichosis, localized, autosomal recessive  37.414  Gene Report
HCA hypercalciuria, absorptive  36.406  Gene Report
Dst dystonin  31.741  Gene Report
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1  28.736  Gene Report
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1  21.264  Gene Report
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7  21.117  Gene Report
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5  21.069  Gene Report
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6  20.668  Gene Report
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13  20.628  Gene Report
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1  20.302  Gene Report
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2  20.261  Gene Report
LOC498196 similar to Cytochrome P450 3A2 (CYPIIIA2) (P450-PCN2) (P450/6-beta-A) (Testosterone 6-beta-hydroxylase)  20.173  Gene Report
Cyp3a3 cytochrome P450, subfamily 3A, polypeptide 3  20.172  Gene Report
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1  20.154  Gene Report
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9  20.135  Gene Report
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2  20.052  Gene Report
LOC502310 similar to cytochrome P450 2B15  19.702  Gene Report
Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13  19.701  Gene Report
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6  19.126  Gene Report
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Related Disease
20/20 shown
Name  
CARCINOMA, HEPATOCELLULAR  
BODY WEIGHT  
INFECTION  
HYPERPLASIA  
INFLAMMATION  
CARCINOMA  
BRONCHIAL HYPERREACTIVITY  
LIVER NEOPLASMS  
DRUGS  
STRESS  
EOSINOPHILIA  
NEOPLASMS, EXPERIMENTAL  
PREGNANCY  
TACHYCARDIA  
HEPATITIS  
NERVE  
ASTHMA  
HYPERSENSITIVITY  
LIVER NEOPLASMS, EXPERIMENTAL  
DISEASE MODELS, ANIMAL  
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Related Chemical
20/20 shown
Name  
ARYL HYDROCARBON HYDROXYLASES  
ESTRADIOL  
DIOXINS  
ARNT PROTEIN, HUMAN  
ETHOXYRESORUFIN  
CYTOCHROME P-450 ENZYME SYSTEM  
POLYCHLORINATED BIPHENYLS  
RECEPTORS, DRUG  
ALLERGENS  
ARNT PROTEIN, MOUSE  
OXYGENASES  
CYTOCHROME P-450 CYP1A1  
NUCLEAR PROTEINS  
RECEPTORS, ARYL HYDROCARBON  
OXIDOREDUCTASES  
PYRENE  
HYDROCARBONS  
OVALBUMIN  
ALPHA-NAPHTHOFLAVONE  
CYP1B1  
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Related Tissue
20/20 shown
Name  
MEMBRANE  
LUNG  
TUMOR CELLS, CULTURED  
CELLS  
CELL LINE  
CELLS, CULTURED  
CARDIAC  
MUSCLE  
MICROSOMES, LIVER  
KIDNEY  
HEART  
BLOOD  
SERUM  
NEURONS  
MICROSOMES  
CYTOSOL  
TISSUE  
LIVER  
TISSUES  
HYPOTHALAMUS  
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Domain
InterPro IPR001092 HLH_basic
InterPro IPR011598 HLH_DNA_bd
InterPro IPR001610 PAC
InterPro IPR000014 PAS
InterPro IPR000700 PAS-assoc_C
InterPro IPR013655 PAS_3
InterPro IPR013767 PAS_fold
Pfam PF00010 HLH, 1
Pfam PF00989 PAS, 1
Pfam PF08447 PAS_3, 1
SMART SM00353 HLH, 1
SMART SM00086 PAC, 1
SMART SM00091 PAS, 2
PROSITE PS50888 HLH, 1
PROSITE PS50113 PAC, FALSE_NEG
PROSITE PS50112 PAS, 1
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Sequence
AHR_HUMAN
10 20 30 40 50
MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL
60 70 80 90 100
ASLLPFPQDV INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN
110 120 130 140 150
CRAANFREGL NLQEGEFLLQ ALNGFVLVVT TDALVFYASS TIQDYLGFQQ
160 170 180 190 200
SDVIHQSVYE LIHTEDRAEF QRQLHWALNP SQCTESGQGI EEATGLPQTV
210 220 230 240 250
VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ GKLKYLHGQK
260 270 280 290 300
KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC
310 320 330 340 350
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV
360 370 380 390 400
FRLLTKNNRW TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT
410 420 430 440 450
KLPFMFTTGE AVLYEATNPF PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS
460 470 480 490 500
LNPSSLLAAM MQQDESIYLY PASSTSSTAP FENNFFNESM NECRNWQDNT
510 520 530 540 550
APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY SIMKNLGIDF
560 570 580 590 600
EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ
610 620 630 640 650
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM
660 670 680 690 700
FENWNSNQFV PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF
710 720 730 740 750
ISCNQPVLPQ HSKCTELDYP MGSFEPSPYP TTSSLEDFVT CLQLPENQKH
760 770 780 790 800
GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH THVGQMQYNP VLPGQQAFLN
810 820 830 840 850
KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP DLTSSGFL
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Features
Key From To Length Description
propeptide 1 10 9  
chain 11 848 837  
domain 41 81 40  
domain 111 181 70  
domain 275 342 67  
domain 348 386 38  
DNA-binding region 13 40 27  
compositionally biased region 600 640 40  
sequence variant 517 517 0 P -> S  
sequence variant 554 554 0 R -> K (in dbSNP:rs2066853) 
sequence variant 570 570 0 V -> I (in dbSNP:rs4986826) 
sequence variant 786 786 0 M -> V  
mutagenesis site 381 381 0 V -> A Increases specific ligand binding 
mutagenesis site 381 381 0 V -> D Abolishes specific ligand binding 
mutagenesis site 381 381 0 V -> G No effect on specific ligand binding 
sequence conflict 191 191 0 E -> EG (in Ref. 6) 
sequence conflict 340 341 1 MI -> SD (in Ref. 7) 
sequence conflict 807 848 41 in Ref. 1)in Ref. 1) 
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External Links
SwissProt P35869;
EMBL D16354;BAA03857.1, mRNA
EMBL L19872;AAA16210.1, mRNA
EMBL AC003075;-, NOT_ANNOTATED_CDS, Genomic_DNA
EMBL BC069390;AAH69390.1, mRNA
EMBL BC070080;AAH70080.1, mRNA
EMBL U28063;AAA92082.1, Genomic_DNA
EMBL U27656;AAA92082.1, JOINED, Genomic_DNA
EMBL U27657;AAA92082.1, JOINED, Genomic_DNA
EMBL U28060;AAA92082.1, JOINED, Genomic_DNA
EMBL U28061;AAA92082.1, JOINED, Genomic_DNA
EMBL U28062;AAA92082.1, JOINED, Genomic_DNA
EMBL U28064;AAA92083.1, Genomic_DNA
EMBL U28066;AAA92084.1, Genomic_DNA
EMBL U28065;AAA92084.1, JOINED, Genomic_DNA
EMBL D38044;BAA07235.1, Genomic_DNA
PIR S59514;S59514
UniGene Hs.171189;
IntAct P35869;
TRANSFAC T01795;
Ensembl ENSG00000106546;Homo sapiens
KEGG hsa:196;
HGNC HGNC:348;AHR
MIM 600253;gene
LinkHub P35869;
ArrayExpress P35869;
RZPD-ProtExp A0474;
RZPD-ProtExp IOH36592;
GO GO:0005634;C:nucleus, IDA:UniProtKB
GO GO:0004879;F:ligand-dependent nuclear receptor activity, IDA:UniProtKB
GO GO:0005515;F:protein binding, IPI:IntAct
GO GO:0003700;F:transcription factor activity, IDA:MGI
GO GO:0006915;P:apoptosis, TAS:UniProtKB
GO GO:0007049;P:cell cycle, TAS:UniProtKB
GO GO:0006355;P:regulation of transcription, DNA-dependent, IDA:UniProtKB
GO GO:0006950;P:response to stress, IDA:UniProtKB
GO GO:0009410;P:response to xenobiotic stimulus, IDA:UniProtKB
GO GO:0006366;P:transcription from RNA polymerase II promoter, IDA:UniProtKB
InterPro IPR001092;HLH_basic
InterPro IPR011598;HLH_DNA_bd
InterPro IPR001610;PAC
InterPro IPR000014;PAS
InterPro IPR000700;PAS-assoc_C
InterPro IPR013655;PAS_3
InterPro IPR013767;PAS_fold
Pfam PF00010;HLH, 1
Pfam PF00989;PAS, 1
Pfam PF08447;PAS_3, 1
SMART SM00353;HLH, 1
SMART SM00086;PAC, 1
SMART SM00091;PAS, 2
PROSITE PS50888;HLH, 1
PROSITE PS50113;PAC, FALSE_NEG
PROSITE PS50112;PAS, 1
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